The Science

Duo 101

Developed with leading science and the best from nature, Duo is at the forefront of bridging oral health with systemic wellness.

Jar of Duo whitening toothpaste with wooden toothbrush and bubbles.

Duo 101

How to brush

Wet your toothbrush and pop a tablet in your mouth. Crunch to break it up into tiny bits. You may feel some bits as you start brushing, and that’s okay. Our natural silk foam will build and reach its peak in about 30 seconds.

Crush a tablet between your teeth

Wet your toothbrush

Brush to activate foam

Spit and smile

Watch explainer with Dr. Stevie Roberts

Duo 101

A superior toothpaste

At their core, our tablets were created to be the best toothpaste available. Created by dentists with carefully selected ingredients to clean your teeth, support your oral health, and soothe your gums

Brightly whitens

Strong enough to get out stains, but gentle enough to not strip enamel

Fights plaque & free radicals

Removes build-up, neutralizes acid, and prevents bad bacteria from forming

Relieves sensitivity

Soothes and restores gums, while reinforcing dental tubules to reduce nerve sensitivity

Two bottles of Duo Whitening Toothpaste with lab equipment and mint leaves in the background.

Duo 101

Elevate your routine

We created Duo to elevate your brushing experience beyond the obligatory.

Original with nHa

Immunity with vitamins D3 + B12

Energy with caffeine + vitamin B12

Sleep with melatonin + L-theanine

Inside the Tablet

Formulated by co-founders Stevie Roberts, DMD and Robert Johnson DMD, MD with leading science and the best from nature, Duo improves dental, oral and systemic health.

Superior

Ingredients

VEGAN

GLUTEN-FREE

SLS-FREE

nano-hydroxyapatite (nHa)

Nano-hydroxyapatite, or nHa, is the dentist-backed fluoride alternative in Duo that remineralizes enamel, removes plaque, whitens, and blocks sensitivity.

Xylitol & xanthan gum

Promote saliva production, reduce biofilm, and slow the growth of disease-causing bad bacteria.

Hydrated silica, calcium carbonate & sodium bicarbonate

Balance PH, naturally polish, and whiten without damaging enamel.

Vitamins C & E

Synergistically support periodontal health and soothe and restore gums.

What you
will not find

Detergents like SLS used for foaming that cause dry mouth

Dyes like titanium dioxide to artificially make paste white

Fillers like glycerin made from animal fat for gunky texture

Chemicals that kill good bacteria and harm the oral microbiome

Plastics that end up in our landfills and oceans

Why nHa?

We use a dentist-backed fluoride alternative called nano-hydroxyapatite, which is clinically proven to be just as effective as fluoride- if not more so- at remineralizing teeth.

It's already in your teeth

Teeth are the hardest structure in the body, and they're made of hydroxyapatite, calcium, and phosphate. Nano-hydroxyapatite is a microscopic derivative (hence the "nano") of hydroxyapatite, the natural mineral in your teeth to make them strong. nHa was developed in the 70s by NASA when fluoride wasn't doing enough to help astronauts' tooth degradation in space.

Selected studies:

Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature

Enamel remineralization and repair results of Biomimetic Hydroxyapatite toothpaste on deciduous teeth: an effective option to fluoride toothpaste

The use of hydroxyapatite toothpaste to prevent dental caries

Remineralizes enamel & dentin

The nHa in duo toothpaste easily bonds with its natural counterparts to replenish and heal degraded tooth structure. Enamel is remineralized by penetrating porosities to replace dissolved calcium and phosphate and ultimately forming a new layer of enamel. Dentin is remineralized by penetrating the collagen matrix and providing a scaffold of calcium and phosphate

Reduces sensitivity

Other methods of decreasing sensitivity, such as the potassium found in Sensodyne, only patch the problem of sensitivity by soothing nerves that send pain messages to the brain. nHa directly addresses the cause by plugging open dental tubules -- the access points to nerves -- and preventing painful stimuli from reaching those nerves in the first place. nHa also reduces hydrodynamic sensitivity by protecting the pulp from pressure changes.

Fights plaque

nHa prevents plaque formation by binding the bacteria before it reaches the teeth and periodontal tissues and preventing bad bacteria from forming a direct attachment to the tooth. nHa has been found to reduce biofilm as effectively as the antimicrobial mouth rinse Chlorhexidine without disrupting the oral biofilm with nonspecific causative agents. That means that nHa is as tough on plaque as medicated mouthwash without destroying all the good bacteria in the mouth as well.

Naturally whitens

nHa is naturally white and increases the brightness and whiteness of the tooth surface by remineralization, which also adds to the smoother and glossier appearance. nHA’s effect on whitening is physiological rather than mechanical or chemical, which means it doesn't strip enamel or have the caustic effects of peroxides, which increase dental sensitivity and harm the oral microbiome. For patients that do use peroxide whiteners, the concurrent use of nHa toothpaste has been proven to reduce associated sensitivity.

REASONS WHY
DENTISTS LOVE NHA

The gateway to
systemic health

Science continues to uncover the depth and complexity of the connection between oral health and the health of all major systems in the body.

Duo is packed with science-backed ingredients that support and nourish your oral health, including the microbiome. This is key to reducing risk of oral and systemic disease and to improving overall health outcomes.